Combinatorial diffusion assay used to identify topically active melanocyte-stimulating hormone receptor antagonists.

Y2-Melanocyte-Stimulating Hormone

Peptides of the pro-opiocortin class produce pronounced cardiovascular and natriuretic actions. We have investigated the acute cardiovascular effects of one of the most potent members of this class, y2-melanocyte stimulating hormone (y2-MSH), in rats. Pressor actions of y2MSH administered systemicaMy were eliminated by ganglionic blockade with chlorisondamine. Peripheral cholinergic blockade fa...

Desacetyl-α-melanocyte stimulating hormone and α-melanocyte stimulating hormone are required to regulate energy balance

OBJECTIVE Regulation of energy balance depends on pro-opiomelanocortin (POMC)-derived peptides and melanocortin-4 receptor (MC4R). Alpha-melanocyte stimulating hormone (α-MSH) is the predicted natural POMC-derived peptide that regulates energy balance. Desacetyl-α-MSH, the precursor for α-MSH, is present in brain and blood. Desacetyl-α-MSH is considered to be unimportant for regulating energy b...

-Melanocyte-Stimulating Hormone Inhibits Allergic Airway Inflammation

Constitutively active follicle-stimulating hormone receptor enables androgen-independent spermatogenesis.

Spermatogenesis is regulated by the 2 pituitary gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This process is considered impossible without the absolute requirement of LH-stimulated testicular testosterone (T) production. The role of FSH remains unclear because men and mice with inactivating FSH receptor (FSHR) mutations are fertile. We revisited the role of FS...

Isolation of melanocyte-stimulating hormone from hog pituitary gland.

The present communication is concerned with two substances possessing melanocyte-stimulating hormone (MSH) activity, ar-MSH and /3-MSH, found in hog pituitary gland. The main component, o(-MSH, was isolated by a four-step process consisting of solvent extraction and fractional precipitation, oxycellulose adsorption, counter-current distribution, and paper electrophoresis. a-MSH has been found t...